Asian Pacific Journal of Tropical Biomedicine
Antinociceptive activity of Ricinus communis L. leaves
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Abstract:
Objective: To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL). Methods: Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw. Results: The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in mice. Preliminary phytochemical analysis suggested the presence of saponin, steroids and alkaloids. Conclusions: It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin, steroids and alkaloids in it.
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