Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats
Objective: To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats. Methods: The antiarthritic activity of 70% ethanolic extract of Ajuga bracteosa (EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund’s adjuvant (CFA)-induced chronic immunological arthritis in albino rats. Results: EEAB showed a significant (P<0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis. EEAB exhibited better antiarthritic activity than the standard aspirin. Conclusions: EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases.
This work was financially supported by National Institute of Pharmaceutical Education and Research.
Gaurav Kaithwas, Raju Gautam, Sanjay M Jachak, Arvind Saklani. Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats. Asian Pac J Trop Biomed 2012; 2(3): 185-188.