Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model
Objective: To observe the combination effect of doxorubicin and Citrus hystrix (kaffir lime’s) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats. Methods: Doxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group Ⅰ: doxorubicin (dox) 4.67 mg/kg body weight; GroupⅡ: dox+ChEE 500 mg/kg body weight; Group Ⅲ: dox+ChEE 1 000 mg/kg body weight; Group Ⅳ: ChEE 1 000 mg/kg body weight; Group Ⅴ: untreated (control). Results: ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST. Conclusion: ChEE has potency to be developed as cardioprotector agent in chemotherapy.
Supported by DP2M DIKTI, Ministry of Education, Republic of Indonesia through PKMP 2012 (Grant No. 0071/E5.3/KPM/2012/5184).