Comparison of lipid profile in different grades of non-alcoholic fatty liver disease diagnosed on ultrasound
Objective: To detect and compare serum lipid abnormalities in patients diagnosed with different grades of non-alcoholic fatty liver on ultrasonography. Methods: A total of 70 cases which included 30 males and 40 females, diagnosed as non- alcoholic fatty liver disease (NAFLD) on ultrasound were investigated with serum lipid profile. Then a comparison of lipid abnormalities between different grades of fatty liver diagnosed on ultrasound was done. P value was calculated by using analysis of variance test (ANOVA) and P value <0.05 was considered as statistically significant. Results: Out of 70 cases which were diagnosed as NAFLD on ultrasonography, grade Ⅰ NAFLD cases were 47.15%, grade Ⅱ were 42.85% and grade Ⅲ were 10%. The mean age of the patients was 49.14 years. Male to female ratio was 3:4. Serum triglycerides, total cholesterol, LDL and VLDL levels were raised in 67.14%, 45.71% 34.28%, 25.71% of cases respectively. Low serum HDL levels were seen in 62.85% of patients. On statistical analysis we found increasing grades of NAFLD were significantly associated with increasing values of total cholesterol (P value-0.001), LDL (P value- 0.000) and VLDL (P value-0.003) and decreasing HDL (P value-0.000). Conclusion: Most of the patients of NAFLD in India is asymptomatic, non-diabetic and non-hypertensive. Though liver biopsy is the gold standard method for diagnosis of NAFLD, Ultrasonography which is non-invasive, simple tool, can be used for the early detection of NAFLD in asymptomatic patients.
Funded by the department of radiodiagnosis with approval by institutional ethics committee of G.R. Medical College, Gwalior, Madhya Pradesh. India with Grant no.-GRM/01/15/2009.