Asian Pacific Journal of Tropical Biomedicine
Comparison of lipid profile in different grades of non-alcoholic fatty liver disease diagnosed on ultrasound
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Abstract:
Objective: To detect and compare serum lipid abnormalities in patients diagnosed with different grades of non-alcoholic fatty liver on ultrasonography. Methods: A total of 70 cases which included 30 males and 40 females, diagnosed as non- alcoholic fatty liver disease (NAFLD) on ultrasound were investigated with serum lipid profile. Then a comparison of lipid abnormalities between different grades of fatty liver diagnosed on ultrasound was done. P value was calculated by using analysis of variance test (ANOVA) and P value <0.05 was considered as statistically significant. Results: Out of 70 cases which were diagnosed as NAFLD on ultrasonography, grade Ⅰ NAFLD cases were 47.15%, grade Ⅱ were 42.85% and grade Ⅲ were 10%. The mean age of the patients was 49.14 years. Male to female ratio was 3:4. Serum triglycerides, total cholesterol, LDL and VLDL levels were raised in 67.14%, 45.71% 34.28%, 25.71% of cases respectively. Low serum HDL levels were seen in 62.85% of patients. On statistical analysis we found increasing grades of NAFLD were significantly associated with increasing values of total cholesterol (P value-0.001), LDL (P value- 0.000) and VLDL (P value-0.003) and decreasing HDL (P value-0.000). Conclusion: Most of the patients of NAFLD in India is asymptomatic, non-diabetic and non-hypertensive. Though liver biopsy is the gold standard method for diagnosis of NAFLD, Ultrasonography which is non-invasive, simple tool, can be used for the early detection of NAFLD in asymptomatic patients.
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Funded by the department of radiodiagnosis with approval by institutional ethics committee of G.R. Medical College, Gwalior, Madhya Pradesh. India with Grant no.-GRM/01/15/2009.
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