Asian Pacific Journal of Tropical Biomedicine
Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub-chronic co-administration of chlorpyrifos and cypermethrin in male Wister rats
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Abstract:
Objective: To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats. Methods: Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and Ⅱwere given distilled water and soya oil (2 mL/kg) respectively. Group Ⅲ was administered with melatonin at 0.5 mg/kg only. Group Ⅳ was administered with CPF [7.96 mg/kg (1/10th LDKeywords:
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Supported by Direct Teaching and Laboratory Grant 560599 to the Department of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria, Nigeria
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