Objective: To study the Shock index of Sepsis patients after Continuous blood purification(CBP) treatment and its relationship with Systemic inflammatory response syndrome, immune response. Methods: A total of 88 cases of Sepsis patients in our hospital during June 2012 to May 2016 year underwent continuous blood purification treatment were chosen as research subject, shock index (SI) was compared before and after the treatment, according to the level of SI after treatment all patients were divided into shock group (n＝27) with SI＞0.5, no shock group (n＝61) with SI≤0.5. Serum inflammatory mediators, Th1/Th2 cell immune indexes, immunoglobulin and complement contents between two groups after treatment were compared. Results: The levels of SI in patients with sepsis were significantly lower than that before treatment (P<0.05). Serum contents of inflammatory mediators such as PCT, CRP, HMGB1 in no shock group were lower than those in shock group, contents of Th1 cytokines IL-2, IFN-γwere higher than those in shock group, contents of Th2 cytokines IL-10, IL-13 were lower than those in shock group, contents of IgG, IgM, IgA, C3, C4 were higher than those in shock group (P<0.05). Conclusion:The level of SI decreased in the patients with sepsis after CBP treatment, and the SI level was directly related to the systemic inflammatory response syndrome and the level of immune response.