目的:探讨银杏胶囊联合二级预防药物对高血压合并颈动脉硬化患者内皮损伤、斑块性质的影响。方法:收集高血压合并颈动脉硬化患者并随机分为两组。对照组患者接受常规二级预防药物治疗,观察组患者接受银杏胶囊联合二级预防药物治疗。对比两组治疗前后血清中内皮损伤指标、脂质代谢指标以及颈动脉超声参数的差异。结果:治疗前,两组的内皮损伤指标、脂质代谢指标以及颈动脉超声参数无显著性差异。治疗后,观察组血清中ET、AngⅡ、TC、LDL-C、LpA的含量以及颈动脉超声参数DS、AS的水平低于对照组,血清中NO、HDL-C的含量以及颈动脉超声参数MLD的水平均高于对照组。结论:高血压合并颈动脉硬化患者接受银杏胶囊联合二级预防药物治疗,可有效减轻内皮损伤程度并稳定斑块。

Objective: To study the effect of ginkgo capsules combined with secondary preventive drugs on the endothelial injury and plaque properties of patients with hypertension complicated by carotid atherosclerosis. Methods: A total of 178 patients with hypertension complicated by carotid atherosclerosis who were treated in Chengyue Community Health Service Center of Xisaishan District Huangshi City Hubei Province between February 2015 and January 2017 were collected and randomly divided into two groups. Control group were treated with conventional secondary preventive drugs, and observation group were treated with ginkgo capsules combined with secondary preventive drugs. The differences in serum endothelial injury indexes and lipid metabolism indexes as well as carotid artery ultrasound parameters were compared between the two groups before and after treatment. Results:Before treatment, endothelial injury indexes and lipid metabolism indexes as well as carotid artery ultrasound parameters were not significantly different between two groups. After treatment, serum ET, AngⅡ, TC, LDL-C and LpA contents as well as carotid artery ultrasound parameters DS and AS levels of observation group were lower than those of control group while serum NO and HDL-C contents as well as carotid artery ultrasound parameter MLD level were higher than those of control group. Conclusion: Ginkgo capsule combined with secondary preventive drugs can effectively reduce the endothelial injury and stabilize the plaques in patients with hypertension complicated by carotid atherosclerosis.

R544.1

2015年湖北省教育厅中青年人才项目(B20151901)