目的:研究还原型谷胱甘肽辅助治疗对肝硬化上消化道出血患者血管活性分子、氧化应激反应的影响。方法:选择在本院诊断为肝硬化所致上消化道出血的患者作为研究对象,采用随机数表法分为接受还原型谷胱甘肽联合常规治疗的GSH组以及接受常规治疗的对照组,治疗前及治疗后3天时,检测两组患者血清中肝功能指标、血管活性分子、氧化应激反应分子的含量。结果:治疗后3天时,两组血清中ALT、AST、γ-GT、TBIL、PRA、AT-II、ALD 、MDA、ox-LDL、AOPP、8-OHdG的含量均较治疗前显著降低,SOD、GSH-Px、CAT的含量均较治疗前显著升高且GSH组血清中ALT、AST、γ-GT、TBIL、PRA、AT-II、ALD 、MDA、ox-LDL、AOPP、8-OHdG的含量均较对照组降低,SOD、GSH-Px、CAT的含量均较对照组显著升高。结论:还原型谷胱甘肽辅助治疗用于肝硬化上消化道出血能够改善肝功能、调节血管活性分子分泌、减轻氧化应激反应。

Objective: To study the effect of adjuvant reduced glutathione therapy on vasoactive molecules and oxidative stress in patients with cirrhosis-induced upper gastrointestinal hemorrhage. Methods: Patients diagnosed with cirrhosis-induced upper gastrointestinal hemorrhage in No. 215 Hospital of Shaanxi Nuclear Industry between June 2015 and March 2017 were selected as the research subjects, and random number table was used to divide them into the GSH group who accepted reduced glutathione combined with conventional therapy and the control group who accepted conventional therapy. Serum levels of liver function indexes, vasoactive molecules and oxidative stress reaction molecules in two groups of patients were detected before treatment and 3 days after treatment. Results:3 days after treatment, serum ALT, AST, γ-GT, TBIL, PRA, AT-II, ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of both groups of patients were significantly lower than those before treatment while SOD, GSH-Px and CAT levels were significantly high than those before treatment, and serum ALT, AST, γ-GT, TBIL, PRA, AT-II, ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of GSH group were significantly lower than those of control group while SOD, GSH-Px and CAT levels were significantly higher than those of control group. Conclusion: The adjuvant reduced glutathione therapy for cirrhosis-induced upper gastrointestinal hemorrhage can improve the liver function, regulate the secretion of vasoactive molecules and reduce the oxidative stress response.

R657.3+1

陕西省自然科学基金项目(2017JM8163)