目的:探讨维生素C联合维生素E对血液透析患者抗氧化力、炎症反应状态的影响。方法:收集在本院接受血液透析治疗的尿毒症患者116例,随机分为对照组及观察组各58例。对照组接受维生素C干预、观察组接受维生素C联合维生素E干预。对比两组干预前及干预后6周时血清中抗氧化指标、促炎介质、抗炎介质含量的差异。结果:干预前,两组血清中抗氧化指标、促炎介质、抗炎介质含量的差异不显著。干预后,两组血清中SOD、GSH-PX、T-AOC的含量均高于治疗前,IL-1、IL-2、IL-6、IL-8、IL-4、IL-10、IL-13的含量均低于治疗前且观察组患者血清中SOD、GSH-PX、T-AOC的含量均高于对照组,IL-1、IL-2、IL-6、IL-8、IL-4、IL-10、IL-13的含量均低于对照组。结论:血液透析患者接受维生素C联合维生素E干预,可有效增强机体的抗氧化力并抑制全身炎症状态。

Objective: To study the effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis. Methods: 116 patients with uremia who received hemodialysis in the hospital between December 2014 and January 2017 were collected and divided into control group and observation group by random number table, each with 58 cases. Control group received vitamin C intervention, and observation group received vitamin C combined with vitamin E intervention. The differences in serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were compared between the two groups before intervention and 6 weeks after intervention. Results:Before intervention, serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were not significantly different between the two groups. After intervention, serum SOD, GSH-PX and T-AOC levels of both groups of patients were higher than those before treatment while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those before treatment, and serum SOD, GSH-PX and T-AOC levels of observation group were higher than those of control group while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those of control group. Conclusion: Vitamin C combined with vitamin E intervention can effectively enhance the antioxidant capacity and suppress the systemic inflammatory state in patients with hemodialysis.

R692.5

长江大学黄冈临床医学院(WJ2016-YZ-44)