目的:研究间歇无氧运动联合吸入剂治疗对哮喘患儿气道重塑、炎症反应的影响。方法:选择在自贡市第三人民医院诊断为支气管哮喘的92例患儿作为研究对象,随机分为运动组、对照组,分别接受间歇无氧运动联合吸入剂治疗、常规吸入剂治疗。结果:干预后4、8周时,两组血清中MMP2、MMP3、MMP9、ADAM33、TGF-β1、Smad3、CTGF、PINP、PIIINP、IL-4、IL-9、IL-21、TNF-α、hs-CRP的含量均显著低于干预前,TIMP1的含量均显著高于干预前且运动组血清中MMP2、MMP3、MMP9、ADAM33、TGF-β1、Smad3、CTGF、PINP、PIIINP、IL-4、IL-9、IL-21、TNF-α、hs-CRP的含量均显著低于对照组,TIMP1的含量均显著高于对照组。结论:间歇无氧运动联合吸入剂治疗能够改善哮喘患儿的气道重塑及炎症反应。

Objective: To study the effect of intermittent anaerobic exercise combined with inhalant therapy on airway remodeling and inflammatory response in children with asthma. Methods: A total of 92 children who were diagnosed with bronchial asthma in Zigong Third People's Hospital between June 2015 and February 2017 were selected as the research subjects and randomly divided into exercise group and control group receiving intermittent anaerobic exercise combined with inhalant therapy and regular inhalant therapy respectively. Results: Four and eight weeks after intervention, serum MMP2, MMP3, MMP9, ADAM33,TGF-β1, Smad3, CTGF, PINP, PIIINP, IL-4, IL-9, IL-21, TNF-α and hs-CRP levels of both groups of patients were significantly lower than those before intervention while TIMP1 levels were significantly higher than those before intervention. Moreover, serum MMP2, MMP3, MMP9, ADAM33,TGF-β1, Smad3, CTGF, PINP, PIIINP, IL-4, IL-9, IL-21, TNF-α and hs-CRP levels of exercise group were significantly lower than those of control group while TIMP1 levels were significantly higher than those of control group. Conclusions: Intermittent anaerobic exercise combined with inhalant therapy can improve airway remodeling and inflammatory response in children with asthma.

R562.2+5

自贡市科技局课题项目(2014z32)