Objective: To investigate the paclitaxel plus cisplatin (TP) neoadjuvant chemotherapy combined with laparoscopic surgery in the treatment of locally advanced cervical cancer and molecular markers on the patients and the efficacy of immune function. Methods: Selected from 92 patients with locally advanced cervical cancer,and on the basis of admission number is divided into the control group (n=46) and treatment group (n=46),the control group given 5 - fluorouracil plus cisplatin (PF),neoadjuvant chemotherapy combined laparoscopic cervical cancer radical new adjuvant chemotherapy combined laparoscopic treatment group given TP cervical cancer radical prostatectomy. The clinical efficacy of the two groups was compared and compared. To detect and compare the level of molecular markers and the changes in immune function in two groups of patients; The adverse reactions occurred in two groups. Results:After chemotherapy,the treatment group 39.13% CR,PR is 41.30%,13.04%,NC PD was 6.52%,total effective rate was 80.43%,the control group were 21.74%,26.09%,30.43%,26.09%,the total effective rate was 47.83%,total effective treatment group was obviously higher than that of control group (P<0.05); There was no significant difference in the incidence of adverse reactions (P>0.05). The levels of CEA,scc-ag,cyfra21-1 and CA125 were significantly lower in 2 weeks after surgery (P<0.05 or P<0.01),and the treatment group was significantly lower than the control group (P<0.05 or P<0.01). Both the mp-2,timp-2,vegf-c and vegf-d levels were significantly lower (P<0.01),and the treatment group was significantly lower than the control group (P<0.01). Both CD3+,CD4+,and CD8+ were significantly reduced in 2 weeks after operation,and the CD4+ / CD8+ ratio was significantly higher (P<0.01),but no significant difference between the two groups (P>0.05). Conclusion:To give TP neoadjuvant chemotherapy in patients with locally advanced cervical cancer combined laparoscopic surgery,can obviously improve the patient's clinical curative effect,reduce the molecular markers in the body,and can effectively improve the patient's immune function,and less adverse reaction,the effect is exact,safe and reliable.