Objective: To evaluate the systemic inflammatory and stress response in patients with COPD complicated by pulmonary infection after bronchoalveolar lavage with ambroxol hydrochloride. Methods:78 patients with COPD complicated by acute pulmonary infection who were treated in the hospital between October 2015 and January 2017 were collected as research subjects and divided into control group (n=39) and study group (n=39) by random number table. Control group received routine treatment, and study group received the routine + bronchoalveolar lavage with ambroxol hydrochloride. The differences in serum levels of inflammatory factors and oxidative stress indexes were compared between the two groups before treatment and after 1 week of treatment. Results: There was no statistically significant difference in serum levels of inflammatory factors and oxidative stress indexes between the two groups before treatment. After 1 week of treatment, serum inflammatory factors IL-2, IL-6, IL-8, TNF-α, CRP and PCT levels of study group were lower than those of control group; serum oxidation indexes MDA, MPO and AOPPs levels were lower than those of control group while anti-oxidation indexes SOD, T-AOC and GSH-Px levels were higher than those of control group. Conclusion: Bronchoalveolar lavage with ambroxol hydrochloride can significantly inhibit the systemic inflammatory and oxidative stress response and help control the disease in patients with COPD complicated by pulmonary infection.