目的:探讨醒脑静注射液对急性脑出血患者炎性细胞因子及凝血功能的影响。 方法:选择我院收治的急性脑出血患者80例,随机分为观察组和对照组各40例。两组患者均接受对症常规治疗,观察组在此基础上加用醒脑静注射液治疗。两组均持续治疗两周。比较两组治疗前后血清炎性因子:TNF-α、hs-CRP、IL-10以及凝血功能指标:活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(Fib)、凝血酶时间(TT)以及D-二聚体(DD)的水平。结果:治疗前,观察组和对照组的血清炎性因子TNF-α、hs-CRP、IL-10水平以及凝血功能指标APTT、PT、Fib、TT、DD相比较,均无明显差异(P>0.05)。治疗后,两组IL-10水平相较治疗前显著升高(P＜0.05),TNF-α、hs-CRP水平均有显著降低(P＜0.05)；且治疗后观察组IL-10水平明显高于对照组(P＜0.05),TNF-α、hs-CRP水平明显低于对照组(P＜0.05)。治疗后,对照组APTT、Fib、DD水平均显著升高(P＜0.05)；观察组PT、DD水平均显著降低、Fib水平显著升高(P＜0.05)。治疗后组间相比,观察组APTT、PT、DD水平显著低于对照组,Fib水平显著高于对照组,各组间差异对比均有显著性(P＜0.05)。治疗前后两组患者TT水平组内、组间比较均无显著差异(P>0.05)。 结论:醒脑静注射液治疗急性脑出血可明显降低患者血清炎性因子水平并促进凝血功能恢复正常,值得推广。
Objective: To investigate the effect of Xingnaojing Injection on inflammatory cytokines and blood coagulation function in patients with acute cerebral hemorrhage. Method: 80 patients with acute cerebral hemorrhage admitted to our hospital from October 2015 to May 2017 were randomly divided into the observation group and the control group, each with 40 cases. Two groups both received conventional treatment, the observation group were given Xingnaojing injection additional treatment. The two groups were treated for two weeks. Changes of serum inflammatory factors TNF-α, hs-CRP, IL-10 and blood coagulation indexes of activated partial thromboplastin time (APTT), prothrombin time(PT), fibrinogen(Fib), thrombin time(TT) and D- dimer (DD) of two groups were compared. Results: Before treatment, the differences of inflammatory factors TNF-α, hs-CRP, IL-10 and coagulation function indexes APTT, PT, Fib, TT and DD of the two groups were not statistically significant (P>0.05). After treatment, the levels of TNF-α, hs-CRP of the two groups were significantly decreased (P＜0.05), and the IL-10 level of the two groups were significantly increased (P＜0.05); the levels of TNF-α, hs-CRP in observation group were significantly lower than the control group (P＜0.05), and the IL-10 level in observation group were significantly higher than the control group (P＜0.05). After treatment, the levels of APTT, Fib and DD in the control group were significantly increased (P＜0.05); the levels of PT and DD in the observation group were significantly decreased and the Fib level was significantly increased (P＜0.05). After treatment, the levels of APTT, PT and DD in the observation group were significantly lower than those in the control group, and Fib level was significantly higher than that in the control group, these differences were statistically significant (P＜0.05). There was no significant difference of TT levels between the two groups before and after the treatment (P>0.05). Conclusion: Xingnaojing injection treatment of acute cerebral hemorrhage can significantly reduce the level of serum inflammatory factors and promote the restoration of coagulation function. It is worth promoting.