Objective: To investigate the effect of budesonide combined with cetirizine hydrochloride on neurotrophic factor, airway function and chemokines CCL17 and CCL12 in patients with allergic rhinitis. Methods: A total of 123 patients with Allergic Rhinitis were randomly divided into three groups, A group treated with budesonide nasal spray, B group treated with cetirizine hydrochloride, C group treated with budesonide combined with cetirizine hydrochloride, compared the Neurotrophic factors, airway function indexes and chemokines CCL17 and CCL12 levels in three groups were compared. Results: Before the treatments, the three groups of patients in neurotrophic factor, airway function index and chemokines CCL17, CCL22 have no differences (P＞0.05), Compared with before the treatments, after receiving different treatments, the three groups of patients in all indicators were Showed significant differences (P<0.05). In the indexes of neurotrophic factor (NGF, BDNF, NT-3mRNA expression), there was no significant difference (P＞ 0.05) between group A and group B, and group C was lower than group A and B (P <0.05). In airway function indexes (FVC, FEV1 and PEF), A group was significantly higher than B group (P <0.05), C group was significantly higher than A group (P＜0.05); In the chemokines CCL17 and CCL22 indicators, C group was lower than A group, A group was lower than B group, the difference was significant (P＜0.05). Conclusionsl Budesonide combined with cetirizine hydrochloride in the treatment of Allergic Rhinitis, can effectively control the patients' neurotrophic factor, pulmonary ventilation and chemokine CC17, CCL22 indicators, the effect is better than Budesonide alone or Cetirizine hydrochloride.