Objective: To study the correlation of serum inflammatory factors with immune response and stress hormones in patients with cesarean incision infection. Methods: Puerperae who underwent cesarean section and got postoperative incision infection in Maternal and Child Health Care in Lintong between January 2014 and December 2016 were selected as the infection group of the research, and puerperae who underwent cesarean section and were without postoperative incision infection in Maternal and Child Health Care in Lintong during the same period were selected as the control group of the research. The contents of inflammatory factors and stress hormones in serum as well as the contents of immune cells and the levels of erythrocyte immunity indexes in peripheral blood were measured. Results:TNF-α, IL-1, IL-6, IL-8, Cor, NE, INS and AT-II contents in serum of infection group were significantly higher than those of control group; CD3+CD4+T cell and CD16+CD25+NK cell contents as well as DTER, ATER, NTER and FEER levels in peripheral blood were lower than those of control group whereas CD3+CD8+T cell content and FEIR level were higher than those of control group. TNF-α, IL-1, IL-6 and IL-8 contents in serum of infection group were negatively correlated with CD3+CD4+T cell and CD16+CD25+NK cell contents as well as DTER, ATER, NTER and FEER levels in peripheral blood, and positively correlated with CD3+CD8+T cell content and FEIR level in peripheral blood as well as Cor, NE, INS and AT-II contents in serum. Conclusion: The abnormal activation of inflammatory response and the abnormal secretion of inflammatory factors are closely related to the immune response disorder and stress response activation.