Objective: To study the correlation of suppressor of cytokine signaling 3 (SOCS3) expression in placenta of intrahepatic cholestasis of pregnancy (ICP) with maternal Th cell imbalance and placental trophoblast cell damage. Methods: Primiparae who were diagnosed with ICP in Bazhong Hospital of Traditional Chinese Medicine between June 2014 and August 2017 were selected as the ICP group, and the healthy primiparae who gave birth during the same period were selected as the control group. The placenta was collected after delivery to determine the expression of SOCS3, Th cytokines and apoptosis genes. Results: SOCS3 mRNA expression and protein expression as well as IL-4 and IL-13 protein expression in placenta of ICP group were significantly lower than those of control group (P<0.05); IFN-γ, TNF-α, IL-2, p53, Caspase-3, Fas, Caspase-8, Cyt-C and Caspase-9 protein expression were significantly higher than those of control group(P<0.05); IFN-γ, TNF-α, IL-2, p53, Caspase-3, Fas, Caspase-8, Cyt-C and Caspase-9 protein expression in ICP placenta with lower SOCS3 expression were significantly higher than those in ICP placenta with higher SOCS3 expression whereas IL-4 and IL-13 protein expression were significantly lower than those in ICP placenta with higher SOCS3 expression(P<0.05). Conclusion: The low expression of SOCS3 in the ICP placenta can aggravate the imbalance of Th cells and the damage of placental trophoblast cells induced by apoptosis.