Journal of Hainan Medical University(中文版)

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  • 1  海南番木瓜提取物对D‑半乳糖所致衰老模型小鼠抗衰老及学习记忆的影响
    XIONG Yun?yun,ZHOU Yan?ning,XIE Chang?cai,ZHOU Kai,YU Dao?rui
    2022, 28(16):6-12. DOI: 10.13210/j.cnki.jhmu.20220525.002
    [摘要](280) [HTML](0) [PDF 2.54 M](987)
    摘要:
    目的:探索海南番木瓜提取物对D‑半乳糖所致小鼠衰老模型的改善学习记忆障碍和抗衰老的作用。方法:将水迷宫实验筛选认知能力正常的4月龄昆明种小鼠共72只,根据随机平均原则,分为阴性对照组、模型组、吡拉西坦组以及海南番木瓜提取物高、中、低剂量组(400、200、100 mg/kg),共6组,每组12只,海南番木瓜提取物与吡拉西坦组每天以灌胃给药途径给予以上药物,阴性对照与模型两个组以同样的给药途径给予等量0.9% NaCl溶液。各组小鼠每周称重1次;给药的同时,每天用2% D‑半乳糖对除阴性对照组小鼠外各组小鼠进行腹腔注射,阴性对照组小鼠注射0.9% NaCl溶液,共7周。49 d后,通过Morris水迷宫观察小鼠的空间学习记忆能力;后取各组小鼠脑组织分别检测其超氧化物歧化酶(Superoxide Dismutase,SOD)、丙二醛(malondialdehyde,MDA)、过氧化氢酶(catalase,CAT)、一氧化氮合酶(Nitric oxide synthase,NOS)的含量;以HE染色法观察海马组织病理学的改变,Western blot测定脑组织核因子‑E2‑相关因子(Nrf2)蛋白表达水平。结果:海南番木瓜提取物干预衰老模型小鼠后,其高、中、低剂量组可不同程度地缩短小鼠的游泳时间和游泳距离,同时能升高小鼠脑组织SOD、CAT、NOS活力和降低MDA含量;且高剂量组表现最佳,优于吡拉西坦组(P<0.01);同时能通过减少神经元细胞核固缩来改善小鼠海马组织中神经元组织病理学改变,并能呈剂量依赖性提高小鼠脑组织中Nrf2蛋白的表达。结论:海南番木瓜一定程度上有延缓D‑半乳糖所致亚急性衰老小鼠的各项体征,具有一定的抗衰老的作用,其作用可能与Nrf2信号通路有一定的联系。
    2  SARS‑CoV‑2与溃疡性结肠炎生物免疫治疗相关性的研究进展
    KANG Yin?nan,JIE You?cheng,LIU Shan?shan,WANG Jun?ke,LI Chu?yi,YU Xiao?hui,ZHANG Jiu?cong
    2022, 28(16):1-5. DOI: 10.13210/j.cnki.jhmu.20220729.001
    [摘要](232) [HTML](0) [PDF 450.88 K](983)
    摘要:
    新型冠状病毒(SARS‑CoV‑2)感染可导致一系列胃肠道损害。相关研究报道了SARS‑CoV‑2感染可导致溃疡性结肠炎的发生和进展,可能与SARS‑CoV‑2感染引发的细胞因子风暴有关。近日,我们还关注了感染SARS‑CoV‑2是否会加重接受生物免疫治疗UC患者的病情以及接种SARS‑CoV‑2疫苗对这些患者是否安全有效等问题。目前,有关SARS‑CoV‑2、SARS‑CoV‑2疫苗和溃疡性结肠炎之间的相互作用机制尚不完全清楚,需要更多的研究进一步明确其中的关系。
    3  基于中医传承计算平台探索中医药治疗化疗性腹泻用药配伍规律
    高宇,胡少博,邓超,苏菲,贾立群
    2022, 28(7):544-549. DOI: 10.13210/j.cnki.jhmu.20210303.002
    [摘要](73) [HTML](0) [PDF 1.20 M](520)
    摘要:
    目的:基于中医传承计算平台探索分析中医药治疗化疗性腹泻用药思路、配伍规律。方法:以“中医”、“中药”、“化疗”、“腹泻”为主题词,检索中国知网(CNKI)、万方数据库(WanFang)、维普数据库中(VIP),检索时间为自建库以来至2020年11月,筛选下载中医药治疗化疗性腹泻的临床研究文献,运用中医传承计算平台对中药的频数进行统计,并总结出核心处方及挖掘新处方。结果:共检索出相关文献145篇,筛选出目标文献57篇、包括相关处方57个;高频药物依次为白术、茯苓、党参、黄连、炙甘草等;设定置信度为0.7、支持度为10,得到12组核心配伍,聚类分析6类。结论:化疗性腹泻的中医药用药以补虚益气、利水渗湿为主,配以清热、收涩药。基于中医传承计算平台数据挖掘分析出来的方药组合及新方组合可供临床医生参考以及在基层医院推行应用。
    4  溃疡性结肠炎组织中cingulin、claudin-2表达量与菌群紊乱、氧化应激及炎症的相关性
    樊敏学 刘琰 冯义朝
    2018, 13(24):2117-2120, 2124. DOI: 10.13210/j.cnki.jhmu.20181119.001
    [摘要](322) [HTML](0) [PDF 2.80 M](515)
    摘要:
    目的:探讨溃疡性结肠炎组织中cingulin、claudin-2表达量与菌群紊乱、氧化应激及炎症的相关性。方法:选取在本院确诊并作为UC组的UC患者70例,同期至本院进行肠镜体检的结肠息肉患者90例作为结肠息肉组。对比两者肠道病变组织中cingulin、claudin-2蛋白表达量以及粪便标本中菌群分布、血清中氧化应激及炎症相关指标的差异。结果:UC组结肠病灶中cingulin、claudin-2蛋白表达量高于结肠息肉组;肠道内大肠杆菌的计数高于结肠息肉组,双歧杆菌、乳酸杆菌的计数值低于结肠息肉组;血清中氧化应激指标GSH-Px、T-AOC的含量低于结肠息肉组,ROS、LHP的含量高于结肠息肉组;血清中炎症因子IL-4、IL-6、IL-17、IL-23、TGF-β的含量均高于结肠息肉组。相关性分析显示:UC病灶组织中cingulin、claudin-2蛋白表达量与菌群紊乱、氧化应激及炎症反应指标均直接相关。结论:UC病灶中存在cingulin、claudin-2异常高表达,可推进机体肠道菌群紊乱及全身炎症应激反应。
    5  骨肉瘤组织中miR-494、miR-130b下游靶基因的探究
    曹博 史永涛
    2018, 13(24):2103-2106, 2111. DOI: 10.13210/j.cnki.jhmu.20181119.002
    [摘要](84) [HTML](0) [PDF 2.78 M](501)
    摘要:
    目的:研究骨肉瘤组织中miR-494、miR-130b的表达量并探究下游靶基因。方法:收集在延安大学附属医院手术切除的骨肉瘤组织,另取同期关节置换术后的正常骨组织作为对照;抽提miRNA后测定miR-494、miR-130b的表达量,抽提RNA后测定增殖基因、侵袭基因的mRNA表达量,抽提蛋白后测定血管新生分子的蛋白含量。结果:骨肉瘤组织中miR-494、Runx3、ELL2、p16、RECK、TIMP1的表达量以及TSSC3的蛋白含量显著低于正常骨组织,miR-130b、β-catenin、CyclinD1、Sox9、ADAMTS18、CatD、STMN1的表达量以及CEACAM6、VEGF、Ang-2的蛋白含量显著高于正常骨组织;骨肉瘤组织中miR-494与Runx3、ELL2、p16、RECK、TIMP1、TSSC3呈正相关,与β-catenin、CyclinD1、Sox9、ADAMTS18、CatD、STMN1、CEACAM6、VEGF、Ang-2呈负相关,miR-130b与Runx3、ELL2、p16、RECK、TIMP1、TSSC3呈负相关,与β-catenin、CyclinD1、Sox9、ADAMTS18、CatD、STMN1、CEACAM6、VEGF、Ang-2呈正相关。结论:骨肉瘤组织中miR-494的低表达以及miR-130b的高表达能够调控增殖、侵袭基因的表达及血管新生分子的生成。
    6  百令胶囊联合依达拉奉对慢性阻塞性肺病患者免疫功能、抗氧化功能及相关因子水平的影响
    路东明 仇玉平 张文娟 陈建华 卜令颖
    2018, 13(24):2121-2124. DOI: 10.13210/j.cnki.jhmu.20181115.009
    [摘要](175) [HTML](0) [PDF 2.17 M](497)
    摘要:
    目的:探讨百令胶囊联合依达拉奉对慢性阻塞性肺病患者免疫功能、抗氧化功能及相关因子水平的影响。方法:收集2016年3月~2018年3月于我院呼吸内科接受治疗的慢性阻塞性肺病患者160例,随机分为对照组与观察组,每组各80例。对照组患者接受依达拉奉治疗;观察组患者接受百令胶囊联合依达拉奉治疗。分别于治疗前后,检测并比较两组患者T淋巴细胞、超氧化物岐化酶(SOD)、血清丙二醛(MDA)、一氧化氮(NO)、血清转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)及基质金属蛋白酶-9(MMP-9)水平。结果:治疗后,对照组及观察组患者CD3+、CD4+及CD4+/CD8+、SOD及NO水平均显著升高,CD8+、MDA水平显著降低;且治疗后观察组患者T淋巴细胞及抗氧化酶水平变化趋势较对照组患者明显(P<0.05)。治疗后,对照组及观察组患者血清中TGF-β1、MMP-9及TNF-α水平均明显降低,且观察组上述指标变化趋势较对照组明显(P<0.05)。结论:百令胶囊联合依达拉奉治疗慢性阻塞性肺病,可显著增强患者免疫功能及抗氧化功能,缓解机体炎症反应,具有较好的临床疗效。
    7  EASI导联与血清H-FABP、IMA联合检测在冠心病心肌缺血病人诊断中的意义
    郑丽 朱宏英 冯雪虹
    2018, 13(24):2158-2161. DOI: 10.13210/j.cnki.jhmu.20181114.002
    [摘要](189) [HTML](0) [PDF 2.09 M](474)
    摘要:
    目的:探究EASI导联与血清心型脂肪酸结合蛋白(H-FABP)、缺血修饰清蛋白(IMA)联合检测在冠心病心肌缺血病人诊断中的意义。方法:将2016年3月~2018年6月来我院治疗的106例冠心病心肌缺血患者作为观察组,将同期于我院体检的106例健康成年人定义为对照组。比较两组心电图异常率、血清H-FABP、IMA,单项及联合检测诊断冠心病心肌缺血的诊断效能﹑不同联合检测的ROC曲线下面积。 结果: 观察组心电图异常率及血清H-FABP﹑IMA水平高于对照组(χ2=59.483,P=0.000;t=36.306,P=0.000;t=42.837,P=0.000);单独EASI导联﹑血清H-FABP﹑IMA诊断冠心病心肌缺血特异度有统计学差异(χ2=6.134,P=0.047), H-FABP的诊断特异度高于EASI导联、血清IMA(χ2=4.151,P=0.042;χ2=5.403,P=0.020);不同平行联合检测诊断冠心病心肌缺血敏感度﹑阴性预测值有统计学差异(χ2=43.318,P=0.000;χ2=23.424,P=0.000),不同系列联合检测诊断冠心病心肌缺血特异度有统计学差异(χ2=9.969,P=0.007);平行联合检测时EASI导联+H-FABP、H-FABP+IMA、EASI导联+H-FABP+IMA的ROC曲线下面积分别为0.713、0.782和0.914,系列联合检测ROC曲线下面积分别为0.709、0.724和0.883,EASI导联+H-FABP+IMA的ROC曲线下面积高于EASI导联+H-FABP、H-FABP+IMA(P<0.05)。结论: EASI导联与血清H-FABP﹑IMA联合对于诊断冠心病心肌缺血具有重要意义,可以考虑在临床工作中联合应用。
    8  Research of the anxiolytic effect of Baihe Dihuang Decoction
    Fang Huan-Le Han Ning-Juan Li Xiao-Ming Niu Rui Chen Yan-Bin
    2019, 25(5):6-9.
    [摘要](623) [HTML](0) [PDF 0.00 Byte](462)
    摘要:
    Objective: To study the effect of Baihe Dihuang Decoction in improving anxiety and its mechanism of action. Methods: Male mice were randomly divided into 5 groups: blank control group, Baihe Dihuang Decoction high, medium, low-dose group and diazepam group. After continuous intragastric administration for 14 d, the behavioral test of the mouse elevated plus maze experiment and opening test was performed. The brain tissue GABA and Glu content was measured by immunosorbent assay (ELISA). Results: Compared with the blank control group, the middle and high doses of Baihe Dihuang Decoction could increase the time and frequency of movement of the mice in the open cross labyrinth in the open arm and increase the number of times that the mouse entered the central area in the opening test. The anti-anxiety effect also showed an increase in the brain tissue GABA content in mice, ignificantly decreased Glu contents in mice. Conclusion: Baihe Dihuang Decoction has some anxiolytic effect, and antianxiety effect may be related to increasing brain tissue GABA content, decreased Glu contents in mice.
    9  3.0 T磁共振SWI及MRS对新生儿HIE早期诊断影响及相关预测因素的回归分析
    李霞 张伟 刘丹 曾毅文
    2019(1):69-72. DOI: 10.13210/j.cnki.jhmu.20181211.002
    [摘要](234) [HTML](0) [PDF 2.57 M](449)
    摘要:
    目的:探讨3.0 T磁共振头颅磁敏感加权成像(SWI)和波谱成像(MRS)影像分度在新生儿缺氧缺血性脑病(HIE)脑损伤程度评估中的应用价值及HIE早期诊断相关预测因素。方法:选取我院在新生儿科诊断为HIE的患儿60例。比较头颅SWI 与MRS序列检查对颅内出血灶的检出率、损伤脑叶数、临床分度和SWI分度、MRS分度之间相关以及HIE早期诊断相关预测因素。结果:60例HIE患儿的影像检查结果中,SWI的检出率为91.4%,MRS的检出率为100%,不同病情程度的HIE患儿的一般资料比较,差异具有统计学意义(P<0.05);临床分度和SWI分度、MRS分度之间显著相关(P<0.05),但两种影像学方法对于检测临床分度无差异(P>0.05);对于损伤脑叶数的检测,临床分度为轻度时,SWI优于MRS(P<0.05);多因素Logistic回归分析表明羊水粪染、脐带绕颈、Apgar值为HIE独立预测因素(P<0.05)。结论:3.0 T磁共振SWI及MRS作为近年来磁共振新开发的成像技术,对新生儿颅内出血具有高度敏感性。3.0 T磁共振SWI及MRS可无创分析脑内具体生物化学成分水平的变化,从统计学的定量角度反映出更多的生化指标,从而判断出新生儿脑损伤的严重程度。
    10  中西医结合治疗溃疡性结肠炎的疗效及对凝血和炎性因子水平的影响
    王琼 朱晗婷 吴国荣 陈文
    2019(1):5-8. DOI: 10.13210/j.cnki.jhmu.20181206.002
    [摘要](252) [HTML](0) [PDF 2.34 M](435)
    摘要:
    目的:分析中西医结合疗法治疗非特异性溃疡性结肠炎(ulcerative colitis,UC)的疗效及对凝血功能、炎性因子水平的影响。方法:先抽取220名实验对象,要求其是UC活动期患者,并将实验对象随机平均分成对照组和实验组两组。对照组采用单纯西药治疗,实验组在对照组疗法基础上加用中药灌肠治疗。对两组临床疗效进行评价和比较。比较两组在治疗前及治疗后凝血酶原时间(PT)、凝血活酶时间(APTT)、D-二聚体(D-D)、血浆纤维蛋白原(Fib)等凝血指标;比较两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)等血清炎性因子含量。结果:试验组和对照组在临床期间达到预想效果的概率分别达到了97%和75%,可以看出实验组的效果是比对照组要好的试验组的临床有效率和疗效均优于对照组,两组之间存在着不同,有统计学意义(P<0.05)。两组治疗后的血浆Fib水平和血浆D-D水平均较治疗前显著降低,差异有统计学意义(P<0.05),而且观察组治疗后的血浆Fib水平和血浆D-D水平均低于对照组,差异有统计学意义(P<0.05)。两组治疗后的各项血清炎性因子水平均较治疗前降低,差异有统计学意义(P<0.05),而且观察组治疗后的各项血清炎性因子水平均低于对照组,差异有统计学意义(P<0.05)。结论:中西医结合治疗UC患者疗效显著,解决凝血纤溶功能的失衡,有效降低炎症反应程及并发症发生率,促进患者康复。
    11  糖尿病微血管并发症及其相关分子机制研究进展
    曾钢 丁群芳
    2019(1):77-80. DOI: 10.13210/j.cnki.jhmu.20181115.008
    [摘要](165) [HTML](0) [PDF 2.36 M](429)
    摘要:
    随着生产生活方式的改变、饮食结构的变化以及人口老龄化的加剧,糖尿病的发生率和致残率及致死率有逐年升高的趋势。糖尿病的发病原因有多种,可能与遗传因素、环境因素、饮食习惯等多种因素密切相关。危及糖尿病患者生活质量和生存状态的多为其并发症,其中涉及各种大血管并发症和微血管并发症,如糖尿病心肌病、糖尿病肾病、糖尿病脑病及糖尿病足等。本文对糖尿病肾病、糖尿病视网膜病变和糖尿病足的发病的相关分子机制进行论述,为新药研发和临床治疗提供借鉴。
    12  基于网络药理学和分子对接探讨减味膈下逐瘀汤治疗非酒精性脂肪肝作用机制研究
    YANG Jing,ZHAO Yao?wei,NIU Jie,WANG Rui
    2022, 28(16):50-58. DOI: 10.13210/j.cnki.jhmu.20210511.002
    [摘要](102) [HTML](0) [PDF 5.62 M](429)
    摘要:
    目的:基于网络药理学分析减味膈下逐瘀汤治疗非酒精性脂肪肝(non‑alcoholic fatty liver disease,NAFLD)的关键化合物及其作用靶点和通路,以探索其治疗作用的分子机制。方法:利用GEO‑Datasets搜集、筛选患病与正常情况下的差异基因,并绘制热图和火山图,通过TCMSP平台和Drugbank数据库检索减味膈下逐瘀汤中诸药的活性化合物,设定OB≥30%和DL≥0.18为阈值,筛选潜在的活性化合物及作用靶点。构建减味膈下逐瘀汤和NAFLD差异基因分子靶点图,利用STRING数据库获取PPI网络和网络拓扑参数,导入Cytoscape对其进行可视化分析,筛选核心调控基因,同时使用SwissDock平台将筛选得到的主要活性成分与靶点进行分子对接。通过DAVID进行GO生物功能富集分析和KEGG代谢通道富集分析,确定主要通路。结果:通过筛选后得到差异基因377个(127个上调基因及250个下调基因),减味膈下逐瘀汤活性化合物225个,308个对应靶点;筛选得到关键靶标14个,对应化合物168个,关键靶点涉及MYC、FOSL2、FOS等。GO功能富集分析结果显示减味膈下逐瘀汤主要对DNA结合转录激活因子活性表达和RNA聚合酶Ⅱ特异性转录起调节作用;分子对接结果显示主要活性成分槲皮素、黄芩素与VCAM1、HSPB1、MYC、JUN等具有较好的结合活性;KEGG富集分析结果显示,主要涉及IL‑17信号通路、Wnt受体信号通路、NF‑κB信号通路、TNF信号通路及糖尿病并发症中的AGE‑RAGE信号通路等。结论:减味膈下逐瘀汤通过多成分/多靶点的相互作用,实现了从多种途径整体治疗NAFLD的目标。应用网络药理学的方法,为进一步深入研究减味膈下逐瘀汤治疗NAFLD作用机制提供了新的研究途径和科学依据。
    13  Promotional effects of exogenous stimulation with pulsedelectromagnetic fields on skin wound healing in diabetic rats
    Yan Han Ze-Dong Yan Shu-Hua Ge
    2019, 25(5):1-5.
    [摘要](514) [HTML](0) [PDF 0.00 Byte](422)
    摘要:
    Objective: The current study aims to identify the effects of exogenous application of pulsed electromagnetic fields on skin wound healing in diabetic rats, and thus provides experimental evidence for its more scientific clinical application in the future. Methods: The diabetic animal models were established via intraperitoneal injection of streptozotocin in 4-monthold male rats. Fourth eight rats were randomly assigned into the diabetes group (DM) and diabetes coupled with pulsed electromagnetic fields (DM+PEMF) group. Another 24 normal rats were used as the blank control group (Control). Then, all the rats in the three groups were subjected to dorsal surgery for the establishment of soft tissue wound model (circular wound with the diameter of 2 cm). Then, the rats in the DM+PEMF group were subjected to pulsed electromagnetic fields stimulation. Then, 6 rats in each group were sacrificed at Day 5, 12 and 19 post surgery. The glucose levels, wound closure, wound healing time and tissue tensile strength were examined and analyzed. Results: Pulsed electromagnetic fields significantly increased the wound closure rate in diabetic rats at Day 5, 12 and 19 post surgery, decreased overall wound healing period in diabetic rats, and also enhanced tissue tensile strength in diabetic rats at Day 5, 12 and 19 post surgery. Conclusion: Low-intensity pulsed electromagnetic fields can significantly accelerate diabetic wound healing process, and also improve diabetic tissue repair capacity. This study may be helpful for providing more scientific and reasonable experimental evidence for the treatment of pulsed electromagnetic fields on diabetic wound healing in clinics.
    14  IDE基因rs11187007位点多态性与GDM患者胰岛素抵抗、全身炎症反应的相关性
    石娟
    2019(1):29-32. DOI: 10.13210/j.cnki.jhmu.20181115.002
    [摘要](165) [HTML](0) [PDF 2.34 M](396)
    摘要:
    目的:研究胰岛素降解酶(IDE)基因rs11187007位点多态性与妊娠期糖尿病(GDM)患者胰岛素抵抗、全身炎症反应的相关性。方法:选择我院确诊的GDM孕妇作为GDM组、同期产检并分娩的健康孕妇作为对照组。采集外周血并测定IDE基因rs11187007位点的基因型及细胞因子IL-6、IL-10、TNF-α、Chemerin、Omentin-1的含量,采集胎盘并测定IRS-1、IRS-2、GLUT3、GLUT4的表达量。结果:GDM组孕妇外周血中IDE基因rs11187007位点AA基因型的构成比、IL-10及Omentin-1的含量以及胎盘中IRS-1、IRS-2、GLUT3、GLUT4的mRNA表达量均低于对照组,外周血中IDE基因rs11187007位点AG基因型、GG基因型的构成比以及IL-6、TNF-α、Chemerin的含量高于对照组;AG基因型、GG基因型的GDM胎盘中IRS-1、IRS-2、GLUT3、GLUT4的mRNA表达量以及外周血中IL-10、Omentin-1的含量低于AA基因型的GDM胎盘,外周血中IL-6、TNF-α、Chemerin的含量高于AA基因型的GDM孕妇。结论:GDM患者体内IDE基因rs11187007位点等位基因A向G的突变能够加重胰岛素抵抗及全身炎症反应。
    15  近十年中国大学生抑郁症患病率的Meta分析
    王蜜源,刘佳,吴鑫,李磊,郝肖迪,沈庆,黄敏婷,孙瑞华
    2020, 26(09):686-693. DOI: 10.13210/j.cnki.jhmu.20200218.001
    [摘要](35) [HTML](0) [PDF 1.94 M](377)
    摘要:
    目的:估计近十年中国大学生抑郁症患病率,旨在揭示我国大学生抑郁症患病的流行趋势,为日后制定大学生抑郁症的防控策略提供参考依据。方法:计算机检索PubMed、荷兰医学文献数据库(Ebase)、Cochrane图书馆(Cochrane Library)、中国期刊全文数据库(CNKI)、万方数据库(Wangfang)、维普期刊数据库(VIP)中公开发表的关于中国大学生抑郁症患病率的横断面研究,提取相关数据后运用R3.6.1软件进行Meta分析。结果:共纳入相关文献37篇,样本量总计52 622人,近十年中国大学生抑郁症患病率的研究结果分布在8.00%~74.00%,采用随机效应模型计算的总体患病率为31.38%,95% CI为(26.31%,36.44%)。亚组分析结果表明,性别、地区、年级、生源地、文献质量会对研究结果产生一定影响。结论:近十年来中国大学生抑郁症的患病率存在着升高的趋势,高校需要加强对大学生心理健康问题的关注。
    16  
    万兴,闫慧新,陶琦,于建,邵铭熙
    .
    [摘要](21) [HTML](0) [PDF 240.87 K](359)
    摘要:
    17  Advances in endoscopic diagnosis of early gastric cancer
    Xia Li Hong-Gang Yu
    2019, 25(5):69-72.
    [摘要](399) [HTML](0) [PDF 0.00 Byte](313)
    摘要:
    Gastric cancer is one of common malignant tumors in clinic. It has high incidence, high mortality and poor prognosis. Generally, gastric cancer is divided into early gastric cancer (EGC) and advanced gastric cancer. The 5-year survival rate of EGC is higher than that of advanced gastric cancer. In recent years, with the continuous development of science and technology, a variety of medical instruments and technologies have been updated, greatly promoting the detection rate of EGC, reducing the rate of EGC missed diagnosis. This article reviews the progress of EGC endoscopic diagnosis.
    18  Effects of routine rehabilitation therapy combined with low frequency electrical stimulation on monoamine neurotransmitters, NSE, ET-1 and cerebral hemodynamics in children with cerebral palsy
    Sai Xun Pei-Pei Wang Nuan Yang Mei Hou Jun Chen Dian-Rong Sun Jian-HuiZhao Li-Ping Lyu
    2019, 25(5):61-64.
    [摘要](351) [HTML](0) [PDF 0.00 Byte](311)
    摘要:
    Objective: To investigate the effects of routine rehabilitation therapy combined with low frequency head stimulation on monoamine neurotransmitters, neuron-specific enolase (NSE), endothelin-1 (ET-1) and cerebral hemodynamics in children with cerebral palsy. Methods: From January 2017 to June 2018, 110 children with cerebral palsy were randomly divided into observation group (55 cases) and control group (55 cases). The control group received routine rehabilitation treatment, while the observation group received low-frequency head stimulation on the basis of routine rehabilitation treatment. The changes of dopamine (DA), norepinephrine (NE), serotonin (5-HT), NSE, ET-1 levels and mean blood flow velocity of anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA) were compared in two groups. Results: Before treatment, there was no significant difference in DA, NE and 5-HT levels in two groups. After treatment, DA, NE and 5-HT levels in the observation group were (192.23±22.71) ng/mL, (98.02±11.71) ng/L, (210.07±25.03) ng/L, and in the control group. the DA, NE, 5-HT levels were (147.06±17.02) ng/mL, (83.07±11.15) ng/L, and (171.88±20.45) ng/L, respectively. The DA, NE and 5-HT levels in two groups were higher than those before treatment, and DA, NE and 5-HT levels in the observation group were higher than those in the control group. Before treatment, there was no significant difference in NSE and ET-1 levels between the two groups. After treatment, the NSE and ET-1 levels in the observation group were (7.97±2.07) μg/L and (41.01±10.07) pg/ mL, and the NSE and ET-1 levels in the control group were (10.38±3.02) μg/L, (58.46±15.02) pg/ mL, respectively. the NSE and ET-1 in two groups were lower than those before treatment, and the NSE and ET-1 of the observation group were lower than the control group. Before treatment, there was no significant difference in mean blood flow velocity between ACA, MCA and PCA. After treatment, the mean blood flow velocities of ACA, MCA, and PCA in the observation group were (46.88±7.72) cm/s, (59.85±10.18) cm/s, and (49.15±7.02) cm/s, respectively, which was significantly higher than before treatment and higher than that of the control group in the same period. Conclusion: Conventional rehabilitation combined with low-frequency electrical stimulation of the head can effectively increase the content of monoamine neurotransmitters in children with cerebral palsy, enhance cerebral blood circulation, and reduce brain damage
    19  CYP correlation study of refractory schizophrenia drug gene detection
    Qin-Wei Xu Xiang-Lai Liu Qian-Kun Yao Zai-Ji Zheng
    2019, 25(5):65-68.
    [摘要](331) [HTML](0) [PDF 0.00 Byte](308)
    摘要:
    Objective: To study the refractory factors associated with schizophrenia. Methods: 200 patients with refractory schizophrenia and 200 patients with non-refractory schizophrenia were selected. The CYP series of genes CYP1A2, CYP3A4 and CYP2D6 were detected by drug gene, and the rapid metabolic probabilities of the three genes were compared and analyzed. 200 patients with refractory schizophrenia were randomly divided into two groups: the combined drug treatment group and the single drug treatment group. The results were compared between the treatment of 0W and 4W for drug gene detection, 3 genes fast metabolizing type and BPRS scale. analysis. Results: The rapid metabolizing probability and non-refractory difference of CYP1A2, CYP3A4 and CYP2D6 genes in patients with refractory schizophrenia were significant. The comparison of fast metabotropic probabilities of CYP1A2, CYP3A4 and CYP2D6 genes in patients treated with 4W after treatment There was no significant difference in the single drug treatment group. The BPRS scale score was significantly higher in the drug-treated group than in the single-drug group. After logistic regression analysis, the refractory characteristics of schizophrenia and The CYP series of genes CYP1A2, CYP3A4, and CYP2D6 are rapidly metabolized. Conclusion: CYP series of genes CYP1A2, CYP3A4, CYP2D6 fast metabolites are related factors of refractory schizophrenia, antipsychotic drugs combined with CYP enzyme inhibitor treatment can improve the efficacy.
    20  Development and prospects of cervical laminoplasty
    Wen-Xuan Wang Bin Zhao Xiao-Feng Zhao Shao-Wei Wang
    2019, 25(5):73-76.
    [摘要](508) [HTML](0) [PDF 0.00 Byte](300)
    摘要:
    Cervical laminoplasty surgery is an alternative to laminectomy. It can increase the space of the spinal cord available by raising the lamina, and achieve the indirect decompression effect to treat cervical spondylosis. Various techniques of laminoplasty have since been developed after two prototype techniques: Hirabayashi’s open-door laminoplasty and Kurokawa’s double-door laminoplasty. Several studies report superior biomechanical stability of the cervical spine after laminoplasty compared with laminectomy. Recent development in laminoplasty is preservation of muscle attachment, which enabled dynamic and static stabilization of the cervical spine by neck extensor muscles. After treatment with new laminoplasty techniques with active postoperative neck muscle exercises, postoperative instability, kyphosis, axial neck pain, and loss of ROM become minimal. The development,complications and future trends of cervical laminoplasty are summarized below.

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