Value of Zhuang medicine Choerospondias axillaris bark for evaluating the expression of PTEN, VEGF in chronic wounds rats
Objective: To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine Choerospondias axillaris bark. Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 groups:normal group, model group, MEBO group, choerospondias group. The normal group and model group were given external deposited normal saline external application. MEBO group used MEBT/MEBO. Choerospondias group was given external deposited choerospondias axillaris bark water decoction external application. Detected cell ultrastructure, PTEN, VEGF mRNA after 12 d. Results: The organelle structure in MEBO group and choerospondias group were restored. In 12 d, PTEN in MEBO group and choerospondias group were lower, VEGF were higher than 1d (P<0.05). PTEN in MEBO group and choerospondias group were lower, VEGF were higher than model group (P<0.05). MEBO group had no difference with choerospondias group (P>0.05). Conclusion: Choerospondias axillaris bark water decoction could remarkably improve the cell ultrastructure in chronic wounds, regulate the PTEN signal conduction effect, and promote wound healing.
1. Natural Science Research Project of Guangxi University of Traditional Chinese Medicine; 2. Qihuang Project of Guangxi University of Traditional Chinese Medicine. Project No:1. 2016MS008; 2. 2018005.