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    2021,1(1), DOI:
    Abstract:
    Objective: To access the complete immunization coverage among children aged 18-23 months living in rural area of Mon State, Myanmar, and study the affecting factors. Method: A cross-sectional study conducted in rural area of Mon State during 2017. Altogether 353 caregivers who had children aged 18 to 23 months were selected using multistage random sampling. Face-to-face interview was applied in data collection. Complete immunization status was defined according to the current practice of routine immunization in Myanmar. Chi-square test and multivariate logistic regression analysis were utilized in data analysis. Results: Most of the caregivers were mothers (86.1%). Among 353 children, 293 [83% (95% CI: 79.1 to 86.9)] had been immunized completely. Majority of caregivers had good levels of knowledge (77.1%) and attitude (71.4%) towards routine immunization. Some children (17.6%) had minor adverse events after immunization such as fever, pain and redness at the site of vaccination. The present study identified that caregivers’ knowledge and attitude towards immunization, and the occurrence of adverse events after immunization in previous immunization session were significantly related to the status of complete immunization coverage (P< 0.001). Conclusion: Complete immunization coverage among children living in rural area of Mon State should be improved. Health education campaigns with appropriate strategies should be reinforced or strengthened in order to enhance caregivers’ knowledge and attitude towards immunization. The occurrence of AEFI should also be solved and thoroughly explained to the caregivers.
    2021,1(1), DOI:
    Abstract:
    President Xi Jinping, at a CPC conference on press and public opinion, pointed out that in the new era the responsibilities and missions of CPC’s press and public opinion are to hold high the banner towards the right direction, focus on the core task and serve the overall situation, unite and inspire the people, cultivate a new social trend among the people, clarify the truth and distinguish right from wrong, bridge China and the rest of the world. He stressed that all the work of the CPC's media and public opinion should adhere to the unity of the Party spirit and the people's nature, turn the Party's theories, lines, principles and policies into the people's conscious actions, reflect the experience created by the people and the actual situation faced by the people in time, enrich the people's spiritual world and enhance the people's spiritual strength. This important address will play a crucial role in guiding various media to report the development of the novel coronavirus epidemic, reflecting the voice of the people, guiding the correct public opinion and supervising the work of epidemic prevention and control. The media are responsible for timely, accurate and all-round reporting of the epidemic situation, fully exercising their right of speech, guiding the correct direction of public opinion, and maintaining social stability.
    2021,1(1), DOI:
    Abstract:
    As of 8:41 AM on April 1, 2020, 771,618 total confirmed cases of COVID-19 have been reported in 203 countries and territories, resulting in 38,394 deaths. The global distribution of the coronavirus disease 2019 (COIVD-19) has the following characteristics: first, it is mainly found in the mid-latitudes of the northern hemisphere, with relatively few confirmed cases in tropical countries. Second, population mobility is thought to be the main cause of transmission for the COVID-19. Third, the strategies and ways to cope with the COVID-19 pandemic differ, since national conditions, epidemic development stage, political system and political will, medical resources and infrastructure, population size and composition, social culture and public will and some other factors are all different. The global response to the COVID-19 pandemic has roughly formed the Chinese mainland pattern, the developed countries (territories) pattern in east Asia and southeast Asia and the developed countries pattern in Europe and America.
    2021,1(1), DOI:
    Abstract:
    Objective: To evaluate the potential of Phenol-Explorer database?containing 751 different food borne polyphenols against the M protease (Mpro) (Protein data bank Id: 6LU7) of SARS-CoV-2 and to find potential structural leads for its inhibition from daily food. Methods:?Molecular modeling, virtual screening, pharmacokinetics, drug likeness studies, toxicity analysis of potential hits and?N3?(known inhibitor), comparative docking studies of known drugs used in the?clinical application for the treatment of COVID-19. Results:?This study identified six potential polyphenols such as sanguiin, theaflavin gallate, theaflavin digallate, kaempferol, punicalagin and protocatechuic on basis of docking scores?as compared to peptidomimetic inhibitor (N3) of SARS-CoV-2 protein?Mpro. Furthermore, sanguiin and theaflavin derivatives were found to be potential binders of S-glycoprotein. ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) studies predicted that protocatechuic acid with good pharmacokinetics as it showed 1 violation in Lipinski’s rule of Five. Most of the potential polyphenols in the Ames mutagenicity test were negative. Conclusions:?The dietary polyphenols in?black tea?and?berries?hold immense potential to bind with the substrate binding pocket of Mpro and Spike proteins. Top scoring compounds, sanguiin-H-6 and theaflavin digallate, are well established vasodilators. Hence, repurposing these vasodilating compounds for COVID-19 treatment is a highlight of this investigation. The study suggested the dietary intake of?black tea and berries increases resistance towards SARS-CoV-2 in early stages of infection.
    Select AllDeselectExport
    Display Method:
    Select AllDeselectExport
    Display Method:
    2021,1(1), DOI:
    Abstract:
    Objective: To evaluate the potential of Phenol-Explorer database?containing 751 different food borne polyphenols against the M protease (Mpro) (Protein data bank Id: 6LU7) of SARS-CoV-2 and to find potential structural leads for its inhibition from daily food. Methods:?Molecular modeling, virtual screening, pharmacokinetics, drug likeness studies, toxicity analysis of potential hits and?N3?(known inhibitor), comparative docking studies of known drugs used in the?clinical application for the treatment of COVID-19. Results:?This study identified six potential polyphenols such as sanguiin, theaflavin gallate, theaflavin digallate, kaempferol, punicalagin and protocatechuic on basis of docking scores?as compared to peptidomimetic inhibitor (N3) of SARS-CoV-2 protein?Mpro. Furthermore, sanguiin and theaflavin derivatives were found to be potential binders of S-glycoprotein. ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) studies predicted that protocatechuic acid with good pharmacokinetics as it showed 1 violation in Lipinski’s rule of Five. Most of the potential polyphenols in the Ames mutagenicity test were negative. Conclusions:?The dietary polyphenols in?black tea?and?berries?hold immense potential to bind with the substrate binding pocket of Mpro and Spike proteins. Top scoring compounds, sanguiin-H-6 and theaflavin digallate, are well established vasodilators. Hence, repurposing these vasodilating compounds for COVID-19 treatment is a highlight of this investigation. The study suggested the dietary intake of?black tea and berries increases resistance towards SARS-CoV-2 in early stages of infection.
    2021,1(1), DOI:
    Abstract:
    As of 8:41 AM on April 1, 2020, 771,618 total confirmed cases of COVID-19 have been reported in 203 countries and territories, resulting in 38,394 deaths. The global distribution of the coronavirus disease 2019 (COIVD-19) has the following characteristics: first, it is mainly found in the mid-latitudes of the northern hemisphere, with relatively few confirmed cases in tropical countries. Second, population mobility is thought to be the main cause of transmission for the COVID-19. Third, the strategies and ways to cope with the COVID-19 pandemic differ, since national conditions, epidemic development stage, political system and political will, medical resources and infrastructure, population size and composition, social culture and public will and some other factors are all different. The global response to the COVID-19 pandemic has roughly formed the Chinese mainland pattern, the developed countries (territories) pattern in east Asia and southeast Asia and the developed countries pattern in Europe and America.
    2021,1(1), DOI:
    Abstract:
    Objective: To access the complete immunization coverage among children aged 18-23 months living in rural area of Mon State, Myanmar, and study the affecting factors. Method: A cross-sectional study conducted in rural area of Mon State during 2017. Altogether 353 caregivers who had children aged 18 to 23 months were selected using multistage random sampling. Face-to-face interview was applied in data collection. Complete immunization status was defined according to the current practice of routine immunization in Myanmar. Chi-square test and multivariate logistic regression analysis were utilized in data analysis. Results: Most of the caregivers were mothers (86.1%). Among 353 children, 293 [83% (95% CI: 79.1 to 86.9)] had been immunized completely. Majority of caregivers had good levels of knowledge (77.1%) and attitude (71.4%) towards routine immunization. Some children (17.6%) had minor adverse events after immunization such as fever, pain and redness at the site of vaccination. The present study identified that caregivers’ knowledge and attitude towards immunization, and the occurrence of adverse events after immunization in previous immunization session were significantly related to the status of complete immunization coverage (P< 0.001). Conclusion: Complete immunization coverage among children living in rural area of Mon State should be improved. Health education campaigns with appropriate strategies should be reinforced or strengthened in order to enhance caregivers’ knowledge and attitude towards immunization. The occurrence of AEFI should also be solved and thoroughly explained to the caregivers.
    2021,1(1), DOI:
    Abstract:
    President Xi Jinping, at a CPC conference on press and public opinion, pointed out that in the new era the responsibilities and missions of CPC’s press and public opinion are to hold high the banner towards the right direction, focus on the core task and serve the overall situation, unite and inspire the people, cultivate a new social trend among the people, clarify the truth and distinguish right from wrong, bridge China and the rest of the world. He stressed that all the work of the CPC's media and public opinion should adhere to the unity of the Party spirit and the people's nature, turn the Party's theories, lines, principles and policies into the people's conscious actions, reflect the experience created by the people and the actual situation faced by the people in time, enrich the people's spiritual world and enhance the people's spiritual strength. This important address will play a crucial role in guiding various media to report the development of the novel coronavirus epidemic, reflecting the voice of the people, guiding the correct public opinion and supervising the work of epidemic prevention and control. The media are responsible for timely, accurate and all-round reporting of the epidemic situation, fully exercising their right of speech, guiding the correct direction of public opinion, and maintaining social stability.

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